Build glycans using a library of monosaccharides
This extension provides a library of glycan assets by Dr. Serge Perez, CERMAV at CNRS (https://cermav.cnrs.fr) and http://www.glycopedia.eu.
Assets provided with the library can be found in the Asset Viewer (Ctrl/Cmd+4 or Interface menu > Assets) in the following folders: Carbohydrates, Glycans.
![GlycansInAssetViewer](https://documentation.samson-connect.net/wp-content/uploads/GlycansInAssetViewer.png)
The monosaccharides given in the asset "Carbohydrates" are the Hexoses, Pentoses, and Ketoses. For a given configuration (D) or (L), monosaccharides can occur as alpha-pyranose, beta-pyranose, alpha-furanose, and beta-furanose (i.e. under 8 different 3D structures). These 128 different monosaccharides can be considered templates to derivatives, constructed using the substituents given in the corresponding asset "Substituents".
![CarbohydratesFolderContentInAssetViewer](https://documentation.samson-connect.net/wp-content/uploads/CarbohydratesFolderContentInAssetViewer.png)
The monosaccharides given in the asset "Glycans" are most commonly present in Algae, Glycosaminoglycans (GAGs), N- and O-linked Glycans, and Plant polysaccharides.
![GlycansFolderContentInAssetViewer](https://documentation.samson-connect.net/wp-content/uploads/GlycansFolderContentInAssetViewer.png)
Monosaccharides notations
The description of a monosaccharide obeys the following rules:
<anomeric prefix><prefix for absolute configuration><the monosaccharide code><suffix for ring configuration>_[<O-ester and O-ether substitutions>]
Anomeric prefixes: a for alpha, b for beta.
Absolute configurations: D or L.
Regarding the several conformations that may occur for some saccharides (e.g. Idopyranoses), their descriptors (2S0, 1C4, 4C1) are included within the monosaccharide symbol: _<specific conformation>
Example: a-L-IdopA_2S_2S0.
Graphical representation
The use of graphical representation follows the recommendations of the Symbol Nomenclature for Glycans: https://www.ncbi.nlm.nih.gov/glycans/snfg.html.
Glycans is an extension for SAMSON,
the integrative platform for molecular design.
To use Glycans:
1. Create your free account
and choose a molecular design plan
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2. Download
and install SAMSON on your computer
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3. Come back to this page to add the extension to
your account
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When you restart SAMSON, the extension will be automatically installed
and will be usable directly from within SAMSON.